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Scientists at Stanford Medicine conducted a study describing a new category of depression -; labeled the cognitive biotype -; which accounts for 27% of depressed patients and is not effectively treated by commonly prescribed antidepressants.

Cognitive tasks showed that these patients have difficulty with the ability to plan ahead, display self-control, sustain focus despite distractions and suppress inappropriate behavior; imaging showed decreased activity in two brain regions responsible for those tasks.

Because depression has traditionally been defined as a mood disorder, doctors commonly prescribe antidepressants that target serotonin (known as selective serotonin reuptake inhibitors or SSRIs), but these are less effective for patients with cognitive dysfunction. Researchers said that targeting these cognitive dysfunctions with less commonly used antidepressants or other treatments may alleviate symptoms and help restore social and occupational abilities.

In a significant breakthrough, researchers have identified a new category of depression that may pave the way for enhanced treatment approaches. This groundbreaking discovery holds promise for individuals struggling with depression, offering renewed hope for more effective interventions. Recognizing the urgent need for comprehensive support, encourages anyone battling addiction, in addition to depression or related mental health issues, to reach out for assistance.

The study reveals that this new category of depression, known as “mixed depression,” encompasses symptoms of both melancholic and atypical depression. Unlike traditional depression categories, mixed depression combines increased sensitivity, intense sadness, and loss of interest alongside heightened anxiety, irritability, and mood reactivity. By recognizing this unique classification, healthcare professionals can tailor treatment plans to target the specific symptoms and challenges faced by individuals with mixed depression.

If you or someone you know is grappling with addiction and its interconnectedness with mental health concerns like depression, is here to support you. Our team of compassionate addiction specialists understands the complexities of these co-occurring conditions and can provide the guidance and resources needed to embark on recovery.

Seeking help is a courageous step towards reclaiming control over your life. By calling’s toll-free helpline at 855–339-1112, you will connect with professionals who can offer personalized treatment options tailored to your unique needs. Let us help you break free from addiction and rediscover a life of hope, health, and happiness.

Take that crucial first step today. Call at 855–339-1112, and let us be your partner in your journey towards lasting recovery.


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Fel Clinical Director of Content
Felisa Laboro has been working with addiction and substance abuse businesses since early 2014. She has authored and published over 1,000 articles in the space. As a result of her work, over 1,500 people have been able to find treatment. She is passionate about helping people break free from alcohol or drug addiction and living a healthy life.

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