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Injection of Fentanyl Citrate should only be administered by trained professionals who specialize in intravenous anesthetics. Generally, it is for the management of the effects of opioids, especially on the respiratory system.

  • Before opting for IV administration, make sure that oxygen, intubation, resuscitative equipment, and an opioid antagonist are readily available.
  • Individualize the dose depending on personal factors including body weight, age, underlying pathological conditions, physical status, usage of other types of drugs, surgical procedures involved and type of anesthesia that will be used.
  • Vital signs should be monitored routinely.

Fentanyl Citrate Injections contain Fentanyl which is classified as a Schedule II controlled drug.


Fentanyl is an opioid. As such it exposes its users to several risks including misuse, abuse, as well as addiction. Drug abusers and those who are diagnosed with addiction disorders often seek opioids. Unfortunately, they become subject to criminal diversions.

You should be able to consider such risks before you opt for a Fentanyl Citrate Injection. Several strategies aimed at reducing such risks include the proper storage of the drug and the proper control practices meant for C-II types of drugs.

If respiratory depression is not recognized or treated immediately, this condition can result in respiratory arrest and even death. Sufficient facilities are necessary for ventilation and postoperative monitoring of patients who are administered with doses of anesthetic Fentanyl Citrate Injections. These facilities also need to be fully equipped for handling respiratory depression in varying degrees.

The management of this condition often includes close observation, the use of opioid antagonists, and other supportive measures depending on the clinical status of the patient. The retention of carbon dioxide from an opioid-induced condition may further exacerbate the effects of opioids including sedation.

In order to minimize the risks of developing respiratory depression, a proper dose and titration of a Fentanyl Citrate Injection are necessary.

Just like any other potent opioid, Fentanyl results in a respiratory depression that can be longer than its analgesic effects. The total dosage of opioid agonists that will be administered to the patient should be carefully considered by a licensed practitioner prior to ordering the use of an opioid analgesic, while the patient is recovering from anesthesia. There are various types of conduction anesthesia including peridural anesthesia and spinal anesthesia.  Take note that some anesthetics may change respiration often by blocking the intercostal nerves.

Fentanyl Citrate Injections are also known to alter respiration by other means.

As such, Fentanyl Citrate Injections should only be used as supplementary to such forms of anesthetics. The anesthetist also needs to be familiar with physiological alterations that can take place and be prepared in such cases.

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