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How Long Does Fentanyl Stay In Your System?

Fentanyl is a generic name for an extremely intense sedative that has a fast onset and brief span of activity. It is being manufactured to treat severe and prolonged pain sensations. Recently, it is being prescribed to patients, who have become dependent to opioids like morphine and oxycodone.

  • Fentanyl is available as a sublingual tablet, transdermal patch, buccal tablet,  nasal solution, lozenges, and sprays.
  • It can be also used intravenously.
  • FDA first approved fentanyl in 1968 produced by Johnson & Johnson.
  • Fentanyl is available under different brand names and forms.
  • Duragesic is a fentanyl that comes as a transdermal patch.

Factors That Influence Fentanyl’s Length Of Stay In The Body


Younger people may have a rapid detoxification of Fentanyl that those who are in their golden years. One review demonstrated that after intravenous use of Fentanyl, 65-year olds showed that the drug’s half-life is 15.75 hours contrasted with only 4.42 hours in younger individuals.

Fat Composition In The Body:

Researchers have proposed that people with a high rate of muscle to fat ratio are more likely to hold Fentanyl for a longer time after stopping if compared to those with low muscle to fat ratio. According to them, Fentanyl is exceptionally lipophilic and dissolves in fat tissues. Hence, Fentanyl dispersion in fats is more broad and its dispersal takes longer to execute.

Hereditary Qualities:

There are people who are “quick metabolizers.” Those with moderate metabolic rates, on the other hand, have decreased CYP3A4 isoenzyme capacity and may show more elevated amounts of Fentanyl in their body.


The most active route of Fentanyl metabolites disposal is peeing. Remaining hydrated can increment urinary stream rate, in this manner expanding drug discharge.

Recurrence Of Use:

Constant use of Fentanyl in high dosages will bring about a more prominent level of metabolite collection in the body.

Drug Interactions:

Few other medications may repress the liver’s capacity to brekadown Fentanyl, potentially making it remain in the body longer than it ought to be. Other medications, further, may also have adverse impacts.

How long does Fentanyl stay in the system?

The half-life of Fentanyl basically relies on the method for its use. When intravenously adminstered, it will have faster disposal from plasma compared to when administered via transdermal or transmucosal ways. The half-life time of intravenously regulated Fentanyl is roughly 2 to 4 hours, so it takes around 11 to 22 hours for absolute elimination from the plasma.

Through the years, series of studies have demonstrated that there is significant difference in the length of time it stays within the system and the primary basis is the route of administration. Transdermal route, for instance, has a more drawn out disposal at around 17 hours. The transmucosal Fentanyl, on the other hand, has a shorter half-life time of around 6.6 hours.

While intravenously taken Fentanyl is the quickest to exit the body, the transdermal and transmucosal types both are out within 5 days after the last dose. Dont forget to read “Fentanyl in your urine, how long does it stay in there“?

Rehab Near Me is an addiction treatment blog as well as industry resource for addiction treatment centers, both detox and rehab related.

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