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Memphis is a city in the U.S. state of Tennessee. It is the seat of Shelby County, in the southwesternmost part of the state, and is situated along the Mississippi River. With a population of 633,104 at the 2020 U.S. census, Memphis is the second-most populous city in Tennessee after Nashville. Memphis is the fifth-most populous city in the Southeast, the nation's 28th-most populous overall, as well as the largest city bordering the Mississippi River and third largest metropolitan statistical area behind Greater St. Louis and the Twin Cities on the Mississippi River. The Memphis metropolitan area includes West Tennessee and the greater Mid-South region, which includes portions of neighboring Arkansas, Mississippi and the Missouri Bootheel. One of the more historic and culturally significant cities of the Southern United States, Memphis has a wide variety of landscapes and distinct neighborhoods. The first European explorer to visit the area of present-day Memphis was Spanish conquistador Hernando de Soto in 1541. The high Chickasaw Bluffs protecting the location from the waters of the Mississippi was contested by European settlers as Memphis developed. By 1819, when modern Memphis was founded, it was part of the United States territory. John Overton, James Winchester, and Andrew Jackson founded the city. Based on the wealth of cotton plantations and river traffic along the Mississippi, Memphis grew into one of the largest cities of the Antebellum South. After the Civil War and the end of slavery, the city continued to grow into the 20th century. It became among the largest world markets for cotton and hardwood. Home to Tennessee's largest African-American population, Memphis played a prominent role in the American Civil Rights Movement. Dr. Martin Luther King Jr. was assassinated in 1968 after activities supporting a strike by the city's maintenance workers. The National Civil Rights Museum was established there and is a Smithsonian affiliate institution. Since the civil rights era, Memphis has become one of the nation's leading commercial centers in transportation and logistics. The largest employer is FedEx, which maintains its global air hub at Memphis International Airport. In 2021, Memphis was the world's second-busiest cargo airport. The International Port of Memphis also hosts the fifth-busiest inland water port in the U.S. The Globalization and World Cities Research Network considers Memphis a "Sufficiency" level global city as of 2020. Memphis is a center for media and entertainment, notably a historic music scene. With blues clubs on Beale Street originating the unique Memphis blues sound, the city has been nicknamed the "Home of the Blues". Its music has continued to be shaped by a multicultural mix of influences: country, rock and roll, soul, and hip-hop. The city is home to a major professional sports team, the Grizzlies of the NBA and the Memphis Showboats of the UFL. Other attractions include Graceland, the Memphis Pyramid, Sun Studio, the Blues Hall of Fame and Stax Museum of American Soul Music. Memphis-style barbecue has achieved international prominence, and the city hosts the annual World Championship Barbecue Cooking Contest, which attracts more than 100,000 visitors each year. Higher-level educational institutions include the University of Memphis, Christian Brothers University and Rhodes College.

Tennessee ( TEN-iss-EE, locally TEN-iss-ee), officially the State of Tennessee, is a landlocked state in the Southeastern region of the United States. It borders Kentucky to the north, Virginia to the northeast, North Carolina to the east, Georgia, Alabama, and Mississippi to the south, Arkansas to the southwest, and Missouri to the northwest. Tennessee is the 36th-largest by area and the 15th-most populous of the 50 states. Tennessee is geographically, culturally, and legally divided into three Grand Divisions of East, Middle, and West Tennessee. Nashville is the state's capital and largest city, and anchors its largest metropolitan area. Other major cities include Memphis, Knoxville, Chattanooga, and Clarksville. Tennessee's population as of the 2020 United States census is approximately 6.9 million. Tennessee is rooted in the Watauga Association, a 1772 frontier pact generally regarded as the first constitutional government west of the Appalachian Mountains. Its name derives from Tanasi (ᏔᎾᏏ), a Cherokee town in the eastern part of the state that existed before the first European American settlement. Tennessee was initially part of North Carolina, and later the Southwest Territory, before its admission to the Union as the 16th state on June 1, 1796. It earned the nickname "The Volunteer State" early in its history due to a strong tradition of military service. A slave state until the American Civil War, Tennessee was politically divided, with its western and middle parts supporting the Confederacy and the eastern region harboring pro-Union sentiment. As a result, Tennessee was the last state to secede and the first readmitted to the Union after the war. During the 20th century, Tennessee transitioned from a predominantly agrarian society to a more diversified economy. This was aided in part by massive federal investment in the Tennessee Valley Authority (TVA) and the city of Oak Ridge, which was established during World War II to house the Manhattan Project's uranium enrichment facilities for the construction of the world's first atomic bombs. After the war, the Oak Ridge National Laboratory became a key center of scientific research. In 2016, the element tennessine was named for the state, largely in recognition of the roles played by Oak Ridge, Vanderbilt University, and the University of Tennessee in its discovery. Tennessee has also played a major role in the development of many forms of popular music, including country, blues, rock and roll, soul, and gospel. Tennessee has diverse terrain and landforms, and from east to west, contains a mix of cultural features characteristic of Appalachia, the Upland South, and the Deep South. The Blue Ridge Mountains along the eastern border reach some of the highest elevations in eastern North America, and the Cumberland Plateau contains many scenic valleys and waterfalls. The central part of the state is marked by cavernous bedrock and irregular rolling hills, and level, fertile plains define West Tennessee. The state is twice bisected by the Tennessee River, and the Mississippi River forms its western border. Its economy is dominated by the health care, music, finance, automotive, chemical, electronics, and tourism sectors, and cattle, soybeans, corn, poultry, and cotton are its primary agricultural products. The Great Smoky Mountains National Park, the nation's most visited national park, is in eastern Tennessee.