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Sanford is a city in Lee County, North Carolina, United States. The population was 30,261 at the 2020 census. It is the county seat of Lee County. The geographic center of North Carolina is located northwest of the city, in Chatham County.

North Carolina ( KARR-ə-LIE-nə) is a state in the Southeastern region of the United States. It is bordered by Virginia to the north, the Atlantic Ocean to the east, South Carolina to the south, Georgia to the southwest, and Tennessee to the west. The state is the 28th-largest and 9th-most populous of the United States. Along with South Carolina, it makes up the Carolinas region of the East Coast. At the 2020 census, the state had a population of 10,439,388. Raleigh is the state's capital and Charlotte is its most populous city. The Charlotte metropolitan area, with an estimated population of 2,805,115 in 2023, is the most populous metropolitan area in North Carolina, the 22nd-most populous in the United States, and the largest banking center in the nation after New York City. The Research Triangle, with an estimated population of 2,368,947 in 2023, is the second-most populous combined metropolitan area in the state, 31st-most populous in the United States, and is home to the largest research park in the United States, Research Triangle Park. The earliest evidence of human occupation in North Carolina dates back 10,000 years, found at the Hardaway Site. North Carolina was inhabited by Carolina Algonquian, Iroquoian, and Siouan speaking tribes of Native Americans prior to the arrival of Europeans. King Charles II granted eight lord proprietors a colony they named Carolina after the king and which was established in 1670 with the first permanent settlement at Charles Town (Charleston). Because of the difficulty of governing the entire colony from Charles Town, the colony was eventually divided and North Carolina was established as a royal colony in 1729 and was one of the Thirteen Colonies. The Halifax Resolves resolution adopted by North Carolina on April 12, 1776, was the first formal call for independence from Great Britain among the American Colonies during the American Revolution. On November 21, 1789, North Carolina became the 12th state to ratify the United States Constitution. In the run-up to the American Civil War, North Carolina declared its secession from the Union on May 20, 1861, becoming the tenth of eleven states to join the Confederate States of America. Following the Civil War, the state was restored to the Union on July 4, 1868. On December 17, 1903, Orville and Wilbur Wright successfully piloted the world's first controlled, sustained flight of a powered, heavier-than-air aircraft at Kitty Hawk in North Carolina's Outer Banks. North Carolina often uses the slogan "First in Flight" on state license plates to commemorate this achievement, alongside a newer alternative design bearing the slogan "First in Freedom" in reference to the Mecklenburg Declaration and Halifax Resolves. North Carolina is defined by a wide range of elevations and landscapes. From west to east, North Carolina's elevation descends from the Appalachian Mountains to the Piedmont and Atlantic coastal plain. North Carolina's Mount Mitchell at 6,684 ft (2,037 m) is the highest point in North America east of the Mississippi River. Most of the state falls in the humid subtropical climate zone; however, the western, mountainous part of the state has a subtropical highland climate.