Scientists from Yale and the University of Cologne were able to show that statistical models created by artificial intelligence (AI) predict very accurately whether a medication responds in people with schizophrenia. However, the models are highly context-dependent and cannot be generalized / published in Science.
In a recent study, scientists have been investigating the accuracy of AI models that predict whether people with schizophrenia will respond to antipsychotic medication. Statistical models from the field of artificial intelligence (AI) have great potential to improve decision-making related to medical treatment. However, data from medical treatment that can be used for training these models are not only rare, but also expensive. Therefore, the predictive accuracy of statistical models has so far only been demonstrated in a few data sets of limited size.
In the current work, the scientists are investigating the potential of AI models and testing the accuracy of the prediction of treatment response to antipsychotic medication for schizophrenia in several independent clinical trials. The results of the new study, in which researchers from the Faculty of Medicine of the University of Cologne and Yale were involved, show that the models were able to predict patient outcomes with high accuracy within the trial in which they were developed. However, when used outside the original trial, they did not show better performance than random predictions. Pooling data across trials did not improve predictions either. The study ‘Illusory generalizability of clinical prediction models’ was published in Science.
As the field of artificial intelligence delves into mental health diagnostics, a recent study sheds light on the challenges of achieving generalizability in AI models. The research emphasizes the complexities of creating models that can effectively adapt across diverse populations and underscores the need for continued refinement to ensure reliable mental health assessments.
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Scientists from Yale and the University of Cologne were able to show that statistical models created by artificial intelligence (AI) predict very accurately whether a medication responds in people with schizophrenia. https://t.co/SkKrbH3whe
— RehabNearMe (@RehabNear_Me) January 25, 2024
